Mateu M. Structure and Physics of Viruses. An Integrated Guide 2ed 2025

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Mateu M. Structure and Physics of Viruses. An Integrated Guide 2ed 2025

Textbook in PDF format The second edition of this book provides a completely updated account of the structure, dynamics, and physics of viral particles: from the moment they emerge by self-assembly from viral components produced in the infected cell, through their extracellular stage, until they recognize and infect a new host cell and cease to exist as they lose their physical integrity to initiate a new infectious cycle. New insights into the structure of viruses, their physical properties, and mechanisms of action, derived from results obtained in the last decade, have been included, as well as other (bio)physical techniques to study the structure or dynamics of virus particles and components. These include, among many others, new advances in high-resolution electron cryomicroscopy; novel approaches in the use of electron cryotomography or the application of soft X-ray tomography to study viruses in the infected cell; high-speed atomic force microscopy to study virus assembly and dynamics; and the development of new antiviral drugs and vaccines. as well as of many nanomedical and nanotechnological applications of virus particles. New chapters on the study of viruses inside infected cells and on technological applications of modified viral particles have been included in this second edition. The book is still aimed primarily at Master's students, Ph.D. students, and postdoctoral researchers with degrees in biology, chemistry, physics or related scientific disciplines who have an interest in or are working with viruses. It provides an up-to-date overview of many important concepts, techniques, studies and applications in structural and physical virology for specialized researchers working with viruses, regardless of their field of specialization, covering the latest research together with fundamental concepts and well-established facts. In short, this book is basic enough to be used by undergraduate and Ph.D. students, but advanced and up-to-date enough for experienced scientists with an interest in structural and/or physical virology. The Viral Machine Introduction: The Structural Basis of Virus Function / Mauricio G. Mateu The Basic Architecture of Viruses / José R. Castón Determination of the Structure, Dynamics, and Physical Properties of Viruses Conventional Electron Microscopy, Cryogenic Electron Microscopy, and Cryogenic Electron Tomography of Viruses / José R. Castón and Daniel Luque X-Ray Crystallography of Viruses / Núria Verdaguer, Cristina Ferrer-Orta, and Damià Garriga Nuclear Magnetic Resonance Spectroscopy to Study Virus Structure / José L. Neira Fluorescence, Circular Dichroism and Mass Spectrometry as Tools to Study Virus Structure / José L. Neira Integrative Approaches to Study Virus Structures / David I. Stuart, Hanna M. Oksanen, and Nicola G. A. Abrescia 3D Cryo-Correlative Methods to Study Virus Structure and Dynamics Within Cells / Rocío Arranz, Francisco Javier Chichón, Ana Cuervo, and José Javier Conesa Atomic Force Microscopy of Viruses / Pedro J. de Pablo Optical Tweezers to Study Viruses / J. Ricardo Arias-Gonzalez Structural Foundations of Virus Properties and Functions Assembly of Structurally Simple Icosahedral Viruses / Alberto López-Bueno, Jon Gil-Ranedo, and José M. Almendral Architecture and Assembly of Structurally Complex Viruses / Carmen San Martín Nucleic Acid Packaging in Viruses / María I. Daudén, Mar Pérez-Ruiz, José L. Carrascosa, and Ana Cuervo Maturation of Viruses / Gabriela N. Condezo and Carmen San Martín Virus-Receptor Interactions and Receptor-Mediated Virus Entry into Host Cells / José M. Casasnovas Entry of Enveloped Viruses into Host Cells: Membrane Fusion / Vicente Mas and Jose Antonio Melero Bacteriophage Receptor Recognition and Nucleic Acid Transfer / Mark J. van Raaij Mechanical Properties of Viruses / Pedro J. de Pablo and Mauricio G. Mateu Theoretical Studies on Assembly, Physical Stability, and Dynamics of Viruses / Antoni Luque and David Reguera Applied Structural and Physical Virology Antiviral Agents: Structural Basis of Action and Rational Design / Luis Menéndez-Arias and Federico Gago Design of Novel Vaccines Based on Virus-Like Particles / Juan Bárcena, María Zamora-Ceballos, and Esther Blanco Engineering and Bio/Nanotechnological Applications of Virus Particles / Mauricio G. Mateu and Alejandro Valbuena Index of Virus Names Index of Virus Families General Index