Sachchida N. Neurodegenerative Diseases.Translational Models,..Therapeutics 2024

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Sachchida N. Neurodegenerative Diseases.Translational Models,..Therapeutics 2024

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Textbook in PDF format This reference book provides a comprehensive overview of models and therapeutic approaches against neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. It explores models based on the chemical, induced, cellular, genetic, transgenic, and 3D organoid approaches in neurodegenerative diseases. The book also reviews advantages and limitations of these models in designing the treatment strategies. Additionally, the book covers the emerging field of bioinformatics and its application in modeling various neurodegenerative diseases. Towards the end, the book highlights the role of holistic management, precision medicine, OMICS, and gene therapy against neurodegenerative disorders. It examines the implications and significance of stem cells therapy in translational models of neurodegenerative diseases. This book is an invaluable resource for researchers, neuroscientists, and neurosurgeons for getting in-depth information on the neurodegenerative models and therapeutic approaches. Key Features: Provides a comprehensive overview of neurodegenerative diseases and their modelsExamines the limitations associated with modeling neurodegenerative diseasesPresents novel treatment strategies for Alzheimer's disease using cellular modelsReviews importance of 3D organoid models for therapeutic approaches in Parkinson's diseaseCovers modeling techniques in understanding prion diseasesExplores the role of genetic models in understanding Huntington's disease Preface About the Editors List of Contributors Acknowledgements General Introduction to Different Neurodegenerative Diseases Chemical-Induced Parkinson’s Disease Model and Associated Therapeutic Strategies Recent Advancement in the Treatment of Parkinson’s Disease Cellular Models Relevance of Genetic Model and Linked Therapeutics in Parkinson’s Disease Importance of Newer 3D Organoids Model-Based Therapeutic Approach in Parkinson’s Disease Chemical Induced Alzheimer’s Disease Models with an Emphasis on Therapeutic Significance and Limitation of Natural Products Advancement in the Genetic Model of Alzheimer’s Disease Organoids and Alzheimer’s Disease Importance of Genetic Model in Huntington’s Disease Natural Sources of Drugs for Neurodegenerative Diseases Limitations of Modeling in Different Neurodegenerative Diseases Significance of 3D Organoid Models in Neurodegenerative Diseases Recent Advances in Therapeutics of Rare Neurological Disorders Bioinformatics-Based Modeling in Different Neurodegenerative Diseases and Associated Therapeutic Strategies Holistic Management of Diverse Neurodegenerative Diseases in Different Translational Models Gene Therapy, OMICS Approaches, and Translational Neurodegenerative Models: Recent Advancements and Future Perspectives Implication and Importance of Stem Cell Therapy in a Translational Model of Neurodegenerative Diseases Index