Ward S. The Handbook of Medicinal Chemistry. Principles and Practice 2ed 2023
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Ward S. The Handbook of Medicinal Chemistry. Principles and Practice 2ed 2023
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Textbook in PDF format
Completely revised and updated, the 2nd edition of The Handbook of Medicinal Chemistry draws together contributions from authoritative practitioners to provide a comprehensive overview of the field as well as insight into the latest trends and research. An ideal companion for students in medicinal chemistry, drug discovery and drug development, while also communicating core principles, the book places the discipline within the context of the burgeoning platform of new modalities now available to drug discovery. The book also highlights the role chemistry has to play in wider target validation and translational technologies.
Physicochemical Properties
Synthesis in Medicinal Chemistry
Useful Computational Chemistry Tools for Medicinal Chemistry
Structure-based Design for Medicinal Chemists
Fragment-based Ligand Discovery (FBLD)
Machine Learning in Drug Design
Drug Metabolism
ADME Optimization in Drug Discovery
Molecular Biology for Medicinal Chemists
Assays
In Vitro Biology: Measuring Pharmacological Activity that Will Translate to Clinical Efficacy
Animal Models: Practical Use and Considerations
Bioinformatics for Medicinal Chemistry
Translational Science
Discovery Toxicology in Lead Optimization
Toxicology and Drug Development
Patents for Medicines
Target Validation for Medicinal Chemists
Lead Generation
Lead Optimisation: What You Should Know!
Pharmaceutical Properties – The Importance of Solid Form Selection
The Medicinal Chemistry and Process Chemistry Interface
Clinical Drug Development
SMN2 Splicing Modification by Small Molecules – A Blueprint to Tackle the Underlying Genetic Cause of Many Underserved Diseases
The Discovery of Checkpoint Kinase 1 Inhibitors: From Fragments to Clinical Candidate
Medicinal Chemistry for Neglected Diseases – Malaria, Tuberculosis, Sleeping Sickness, Leishmaniasis and River Blindness
New Therapeutic Chemical Modalities: Compositions, Modes-of-action, and Drug Discovery