Ward S. The Handbook of Medicinal Chemistry. Principles and Practice 2ed 2023

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Ward S. The Handbook of Medicinal Chemistry. Principles and Practice 2ed 2023

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Textbook in PDF format Completely revised and updated, the 2nd edition of The Handbook of Medicinal Chemistry draws together contributions from authoritative practitioners to provide a comprehensive overview of the field as well as insight into the latest trends and research. An ideal companion for students in medicinal chemistry, drug discovery and drug development, while also communicating core principles, the book places the discipline within the context of the burgeoning platform of new modalities now available to drug discovery. The book also highlights the role chemistry has to play in wider target validation and translational technologies. Physicochemical Properties Synthesis in Medicinal Chemistry Useful Computational Chemistry Tools for Medicinal Chemistry Structure-based Design for Medicinal Chemists Fragment-based Ligand Discovery (FBLD) Machine Learning in Drug Design Drug Metabolism ADME Optimization in Drug Discovery Molecular Biology for Medicinal Chemists Assays In Vitro Biology: Measuring Pharmacological Activity that Will Translate to Clinical Efficacy Animal Models: Practical Use and Considerations Bioinformatics for Medicinal Chemistry Translational Science Discovery Toxicology in Lead Optimization Toxicology and Drug Development Patents for Medicines Target Validation for Medicinal Chemists Lead Generation Lead Optimisation: What You Should Know! Pharmaceutical Properties – The Importance of Solid Form Selection The Medicinal Chemistry and Process Chemistry Interface Clinical Drug Development SMN2 Splicing Modification by Small Molecules – A Blueprint to Tackle the Underlying Genetic Cause of Many Underserved Diseases The Discovery of Checkpoint Kinase 1 Inhibitors: From Fragments to Clinical Candidate Medicinal Chemistry for Neglected Diseases – Malaria, Tuberculosis, Sleeping Sickness, Leishmaniasis and River Blindness New Therapeutic Chemical Modalities: Compositions, Modes-of-action, and Drug Discovery