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Yi W. Chemistry and Biology of O-GlcNAcylation 2024

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Yi W. Chemistry and Biology of O-GlcNAcylation 2024

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Category: Other
Total size: 7.12 MB
Added: 2025-03-10 23:39:01

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Info Hash: 420B1049BDBDBE051900F9A1DB3E1530E9DC2777
Last updated: 3.9 hours ago

Description:

Textbook in PDF format O-linked N-acetylglucosamine (O-GlcNAc) is a prevalent post-translational modification of numerous intracellular proteins. This modification has recently emerged as a key regulator of various important biological processes, including gene transcription, stress response, metabolic homeostasis, and immune regulation. Given the critical role of O-GlcNAc in normal physiology, increasing evidence has now demonstrated that deregulation of O-GlcNAc is closely associated with the development and progression of various diseases, including neurodegeneration, cardiovascular disease, and cancer. This book provides a comprehensive overview of the current progress and understanding of this modification in biology, and likely provides new research directions in the future. Chemical Tools for Decoding the Functions of O-GlcNAcylation Profiling O-GlcNAcylation with Mass Spectrometry O-GlcNAcylation and Cell Metabolism O-GlcNAcylation in Transcriptional Regulation and Epigenetics O-GlcNAc and Signal Transduction in Cancer O-GlcNAcylation and Stem Cells O-GlcNAcylation and Immune Regulation O-GlcNAcylation in Neuronal Development, Neurodegeneration, and Neurological Disorders