Lonnberg H. Chemistry of Nucleic Acids 2ed 2024

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Lonnberg H. Chemistry of Nucleic Acids 2ed 2024

Textbook in PDF format Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses main aspects of synthesis, hydrolytic stability and solution equilibria of nucleosides, nucleotides and oligonucleotides, as well as synthesis of their structural analogs that are of interest in chemotherapy. In addition, recent achievements in chemistry of catalytic nucleic acids, development of oligonucleotide based drugs and novel strategies for their targeting and delivery are discussed. The central theme always is the correlation of structure and function. Gives an overview of the chemistry and biology of nucleic acids in an easy-to-grasp manner. Explains the connection between the structure of nucleic acids and their ability to form triple helical and quadruplex frameworks. Nucleosides: structure, nomenclature and solution equilibria Nucleosides: synthesis, transformation reactions and hydrolytic stability Nucleotides Nucleosides and nucleotides in chemotherapy Oligonucleotides: synthesis Oligonucleotides: reactions Oligonucleotide conjugates Nucleic acids: DNA Nucleic acids: RNA Catalytic nucleic acids Nucleic acids as drugs and drug targets 1: oligodeoxyribonucleotides in chemotherapy Nucleic acids as drugs and drug targets 2: RNA in chemotherapy Nucleic acids as drugs and drug targets 3: target recognition and delivery