Nangia A. Supramolecular Synthons in Crystal Engineering of Pharma. Prop. 2025

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Nangia A. Supramolecular Synthons in Crystal Engineering of Pharma. Prop. 2025

Textbook in PDF format This comprehensive resource skillfully consolidates crystal engineering, the design of organic solids, and supramolecular synthons (i.e., structural hydrogen bond units) to achieve desired pharmaceutical properties, including solubility, dissolution, bioavailability, permeability, particle size, tableting, hydration, and mechanical strength. Covering 30 years of crystal engineering developments and pharmaceutical applications, this book will be a single and complete resource for supramolecular and structural chemists, the crystal engineering community, pharmaceutical scientists, and industrial researchers. Key Features: Covers the fundamentals of crystal engineering and supramolecular synthons. Details the challenges of low solubility and low permeability facing oral drug formulations. Explains how heterosynthons provide a rational approach to address and implement solutions. Provides case studies from academic and industrial labs to walk the reader through the actual steps. Explores developments in the scale up and manufacture of crystal forms in pharmaceutical industry. Introduction to Supramolecular Chemistry and Crystal Engineering Crystal Engineering, Supramolecular Synthons, and Cocrystal Design Pharmaceutical Solid-State Forms Design and Methodology of Pharmaceutical Cocrystals Applications of Pharmaceutical Cocrystals Continuous Manufacturing of Cocrystals and Salts Commercial Outlook of Pharmaceutical Cocrystals Controlling Polymorphism Supramolecular Heterosynthon in High Bioavailability Drugs Other Applications of Cocrystals AI ML ChatGPT in Chemistry 3D Electron Diffraction Challenges, Conclusions, and Future Directions