Smith D. Pathogenesis of Neuropathic Pain. Diagnosis and Treatment 2022

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Smith D. Pathogenesis of Neuropathic Pain. Diagnosis and Treatment 2022

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Textbook in PDF format This comprehensive source on the pathogenic origins of neuropathic pain covers the detailed molecular bases of the currently known neuropathies as classified by their pathogenic origins. Filling a critical need, this book fills the need for a resource on a syndrome that demands improved understanding by clinicians and researchers alike so that treatment options for patients are not categorically limited to a pill or a needle. If the clinician understands the origins of a patients' neuropathic pain, they can work cooperatively toward improving it with tailored therapies that don't create societal diseconomies and that ultimately are effective in helping patients. The book presents in detail the molecular bases of some currently known neuropathies by their pathogenetic origins, allowing clinicians to tailor more specific and more effective treatment regimens for their patients. For basic researchers, this book is a general resource to better direct research onneuropathy-specific molecular mechanisms. The improved understanding of the pathogenesis of neuropathic pain can then be used to develop more specific and more effective manipulations of these pathways. Preface Reference Acknowledgments Contributors About the Editors Mechanisms of Chronification of Acute Pain Nerve Growth Factor and Neuropathic Pain Introduction Mechanism of Chronification Clinical Considerations Diabetic Neuropathic Pain Myofascial and Dermatologic Musculoskeletal Disease Urinary Tract Cancer-Induced Bone Pain Therapeutic Research Cannabinoid Receptors TrkA Inhibitors Small Molecule Antagonism of NGF Conclusion References Protein Kinase C and the Chronification of Acute Pain Introduction Protein Kinase Families Protein Kinase Isoforms and the Development of Neuropathic Pain Protein Kinase C Epsilon (PKCε) Protein Kinase C Gamma (PKCγ) PKC Delta (PKC δ) PKM Zeta (PKC ζ) PKC Epsilon (PKCε) Protein Kinase C and Novel Therapeutic Intervention Metalloproteinase Inhibition Flavonoids Chelerythrine IL-10 Manipulation via Viral DNA Transduction Upregulation of Parvalbumin Interneurons Manipulation of DGK Manipulation of Store-Operated Calcium Channels Manipulation of Purinergic Receptors Appendix References Tumor Necrosis Factor-Alpha and the Chronification of Acute Pain Designer Receptor Exclusively Activated by Designer Drugs (DREADD) T-Box Transcription Factor Purinergic Receptor System Kinin Receptor System TNFα-Targeting Therapeutics Genetic Manipulations Translational Manipulation of the Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Genetic Suppression of Poly – (ADP-Ribose) Polymerase (PARP-1) Inhibitors Nanoparticulate Genetic Manipulation of TNF-α Genetically Reduced Responsiveness to TNF-α Genetic Manipulation of Annexin 10 Plant Based TNFα Targeted Therapeutics Naringenin Resveratrol Folashade (Lippia) Bergapten Fumaria Officinalis Conjugated Linoleic Acid Excoecaria Agallocha Aegle Marmelos Tribulus Terrestris Bisabolol Benfotiamine Levo-Corydalmine (I-CDL) (Berberine) Cannabinoids Withania Somnifera B Vitamins Loganin Limonene (LIM) Miscellaneous TNF-α- Targeting Therapies Nucleotide-Binding and Oligomerization Domain (NOD)-like Receptors Exercise Spirocyclopiper-Azinium Angiotensin II Type 1 Receptor Antagonism Gallic Acid Remifentanil Thetanix Oxytocin Hyperbaric Oxygen Paeoniflorin ASK-Inhibitor Modafinil Microglial Manipulation Cytokine – Signaling Protein 3 (SOC 53) in Microglia Acupuncture/Acupressure Pulsed Radiofrequency Pentoxifylline Oxyntomodulin Thalidomide Venflaxine Summary References Tetrodotoxin and Neuropathic Pain Introduction Mechanism of Action Studies on Therapeutic Potential Clinical Application Alternative Voltage-Gated Sodium Channel Blockers Summary References Epigenetic Alterations in the Nervous System in Neuropathic Pain Conclusion References Neuropathic Syndromes Pathogenesis of Neuropathic Pain: Diagnosis and Treatment Complex Regional Pain Syndrome Introduction Definition Pathophysiological Mechanisms Diagnosis Treatment References Chemotherapeutics That Impair Microtubule Function: Axonopathy and Peripheral Neuropathies Introduction Incidence Risk Factors Mechanism of Injury Basic Cell Biology of Microtubules The Role of Microtubules in Mitosis: Rationale for Microtubule Targeting Agents (MTAs) as a Cancer Therapy Microtubules in Neurons and Their Indispensable and Unique Role in Axons Review of Microtubule Targeted Agents (MTA) Microtubule Stabilizers Microtubule Destabilizers Assessment and Diagnosis Preventable Measures to the Development of CIPN Treatments of the Symptoms of CIPN Summary References Diabetic Peripheral Neuropathy Introduction Molecular Mechanisms of Diabetic Neuropathy Galactose Neuropathy and Oxidative Stress Angiotensin Converting Enzyme (ACE) Mediated Neuropathy Transition Metal Mediated Neuropathy - Glycochelates Therapeutics Genetic Treatment of Hemodynamic Derangements Caused By DPN Endothelium-Dependent and Endothelium-Independent Micro-Vasodilatation Therapy Angiotensin-Converting Enzyme Inhibitor Therapy Free Radicals Scavenging Therapy Conclusion References Alcoholic Neuropathy Introduction Supraspinal Effects of Acute and Chronic Ethanol Exposure GABA Receptors Calcium Channels Excitatory Amino Acids Dopamine and Sedation Adenosine Alcoholic Peripheral Neuropathy Molecular Mechanisms Involved in Alcoholic Neuropathy Direct Toxic Effects of Ethanol or its Metabolites Oxidative Stress and Alcoholic Neuropathy Neuroinflammation Protein Kinase Glial Cells Cytoskeletal Effects Clinical Presentation Diagnosis Treatment Liver Transplantation Sodium Channel Blockade Spinal Cord Stimulation Therapy Benfotiamine Alpha Lipoic Acid Acetyl-L-Carnitine Miscellaneous Agents Novel Therapeutics Myo-Inositol N-Acetylcysteine Coenzyme Q 10 Curcumin Rolipram Quercetin Resveratrol Tocotrienol Epigallocatechin-3-Gallate (EGCG) Gene Manipulation Miscellaneous Disulfiram Toxicity Summary References Uremic Neuropathy Introduction Risk Factors Diagnosis of Uremic Neuropathy Mechanisms and Pathogenesis Guanidino Compounds Creatine Creatol Methylglyoxal Guanidine Potassium Parathyroid Hormone Clinical and Laboratory Presentations of Uremic Neuropathy Visual Deterioration Carpal Tunnel Syndrome Pruritus Impaired Cognitive Function Treatment Zinc Retigabine Flumarizine Alpha-Lipoic Acid Gangliosides Benfotiamine Summary References Perfussion-Related Neuropathies Cuban Epidemic Neuropathy Ischemic Monomelic Neuropathy Venous Insufficiency Sympathetic Denervation Neuropathy Hypertension-Related Neuropathy Hypotension-Related Neuropathy References Pressure-Induced Neuropathy and Treatments Introduction Background “Pressure-Induced Neuropathy and Resultant Pain” Animal Studies Tumor Compression Mechanotransduction Channels Glial Activation/Deactivation Studies-Murine Model Chronic Constrictive Injury-Murine Model Human/Clinical Studies Migraine Headache Carpal Tunnel Syndrome Lumbar Radiculopathy Hereditary Neuropathy with Liability to Pressure Palsy (HNPP) Inguinal Entrapment Syndrome Miscellaneous Human Models of PIN Treatments and Summary References Infectious Neuropathies Introduction Prion Disease – Related Neuropathies Viruses Covid-19 Related Neuropathies S-Protein (Spike) Astrocyte and Microglia Responses to Coronavirus Axonopathic Neuropathy Chemokines Axonal Transport Therapeutics Memantine RNase L Protection Remdesivir Corticosteroids Human Immunodeficiency Virus-Related Neuropathies Viral Hepatitides Hepatitis A Virus Hepatitis B Virus Hepatitis C Virus Hepatitis E Virus Human Herpes Viruses Herpes Simplex Virus-1 and Herpes Simplex Virus-2 Varicella Zoster Virus Cytomegalovirus Flaviviruses West Nile Virus Zika Virus Lyssavirus Bacteria Mycobacterium Leprae Lyme Disease Toxins Botulism Diphtheria Tetanus Tick Paralysis Parasite References Index