Shahi M. Role of Signaling Pathways in Brain Tumorigenesis 2023

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Shahi M. Role of Signaling Pathways in Brain Tumorigenesis 2023

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Textbook in PDF format This book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. Finally, the book summarizes the potential early therapeutic targets and targeted drug discovery for brain tumours. Preface Organization of the Book Acknowledgments About the Author Introduction to Cell Signaling Pathways and Brain Tumors Wnt Cell Signaling Pathway in Brain Tumor Development Notch Cell Signaling Pathway and Brain Tumors Sonic Hedgehog Cell Signaling Pathway and Medulloblastoma Role of the Shh Signaling Pathway in the Most Common Brain Tumor “Glioma” role in Glioma Growth NANOG Stem Cell Marker and Its Role in Brain Tumor Development Stem Cell Factor Sox2 and Brain Tumor Development Role of Neurotrophins in Brain Tumor Development Role of NF-kB in Brain Tumor Development Role of Myc in Brain Tumor Development Role of p53 in Medulloblastoma Development Role of TP53 Gene in Glioma Role of HIF-1 in Brain Tumor Development EGFR and Its Role in Glioma Development Role of EFGR in Medulloblastoma Development Role of OCT4 in Glioblastoma Role of OCT4 in Pediatric Brain Tumor “Medulloblastoma” Development Mitogen-activated protein (MAP) kinase Roles in Paediatric Brain Tumor “Medulloblastoma”