Aloe L. NGF and Related Molecules in Health and Disease 2004

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Aloe L. NGF and Related Molecules in Health and Disease 2004

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Textbook in PDF format The book highlights different aspects of current understanding of neurotrophin-receptor signal transduction pathways, including the signaling endosome hypothesis. Findings on the synaptotrophic potential of NGF and related neurotrophins, neurotrophin involvement in neuronal stem cell biology, biological activity of the NGF precursor proNGF, and nociception- and antinociception-associated activity of NGF and/or BDNF are also presented and discussed. Several chapters deal with the involvement of various neurotrophins in the control of different nonneuronal processes, such as immune, inflammatory and allergic reactions, tissue repair and wound healing. The findings showed that neurotrophins play important roles in the pathobiology of a surprising variety of seemingly unrelated non-neurological diseases, including bronchial asthma, rheumatoid arthritis, systemic sclerosis, hair growth disorders, psoriasis, corneal and skin ulcers, atherosclerosis, metabolic syndrome, crush syndrome, and Beh?et's disease. There are also chapters on the involvement of NGF and related molecules in neurological diseases, including Huntington's disease, the multiple sclerosis-like model of experimental allergic encephalomyelitis, peripheral neuropathies, neuroblastoma, Parkinson's disease, Alzheimer's disease, and even motion sickness syndrome, also psychiatric disorders, including depression and schizophrenia. Finally, potential important therapeutic benefits are presented, for diabetic neuropathy, gastrointestinal dysmotility, CNS neurodegenerative disease, spinal cord injuries, cutaneous and corneal ulcers, as well as peripheral ischemic vasculopathy. List of Contributors Preface Trafficking the NGF signal: implications for normal and degenerating neurons The p75 neurotrophin receptor: multiple interactors and numerous functions The role of neurotransmission and the Chopper domain in p75 neurotrophin receptor death signaling The role of NT-3 signaling in Merkel cell development Stem cells and nervous tissue repair: from in vitro to in vivo Pathways of survival induced by NGF and extracellular ATP after growth factor deprivation ProNGF: a neurotrophic or an apoptotic molecule? NGF deprivation-induced gene expression: after ten years, where do we stand? Neural stem and progenitor cells: choosing the right Shc Acute and long-term synaptic modulation by neurotrophins Neurotrophic factors and CNS disorders: findings in rodent models of depression and schizophrenia Discovering novel phenotype-selective neurotrophic factors to treat neurodegenerative diseases Neurobehavioral coping to altered gravity: endogenous responses of neurotrophins Neurotrophic factors in Huntington's disease Neural crest development and neuroblastoma: the genetic and biological link Neurotrophin-3 in the development of the enteric nervous system Neurotrophins in the ear: their roles in sensory neuron survival and fiber guidance Neurotrophin presence in human coronary atherosclerosis and metabolic syndrome: a role for NGF and BDNF in cardiovascular disease? Neurotrophins in spinal cord nociceptive pathways The role of neurotrophins in bronchial asthma: contribution of the pan-neurotrophin receptor p75 Expression of nerve growth factor in the airways and its possible role in asthma Neurotrophins and neurotrophin receptors in allergic asthma Nerve growth factor and wound healing Interactions between the cells of the immune and nervous system: neurotrophins as neuroprotection mediators in CNS injury Role of nerve growth factor and other trophic factors in brain inflammation Remyelination in multiple sclerosis: a new role for neurotrophins? Role of NGF and neurogenic inflammation in the pathogenesis of psoriasis Nerve growth factor: from animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer's disease Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord Neurotrophic factors and their receptors in human sensory neuropathies Epithelial growth control by neurotrophins: leads and lessons from the hair follicle Nerve growth factor, human skin ulcers and vascularization. Our experience The nerve growth factor and the neuroscience chess board Subject Index