Vlasova I. RNA Therapeutics. History,Design,Manufacturing,and Applications 2023

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Vlasova I. RNA Therapeutics. History,Design,Manufacturing,and Applications 2023

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Textbook in PDF format RNA therapies evolved as economical and widely applicable individualized treatment solutions. Novel RNA-based therapeutic vaccines (e.g., against SARS-CoV-2 infection) have been proven to be safe and effective, and many of them are approved by the United States Food and Drug Administration (FDA). This book presents distinct classes of RNA therapeutics, ranging from single-stranded antisense oligonucleotides (ASOs) and subclasses of RNA interferences (miRNAs and other RNAi) to in vitro transcribed and in vivo translated mRNAs drugs and RNA vaccines. The book also discusses some of the challenges in RNA drug engineering, delivery, and specificity, as well as highlights the improvement of pharmacological effectiveness in a wide range of diseases. RNA Drugs Development and Commercialization Prophylactic Ribonucleic Acid Vaccines to Combat RNA Viral Infections in Humans Ribozymes as Therapeutic Agents against Infectious Diseases A New Era of RNA Personalized Vaccines for Cancer and Cancer-Causing Infectious Diseases RNA Therapeutics for Cancers RNA Interference Applications for Machado-Joseph Disease