Maiti D. Directed C-H Bond Functionalization. Concepts and Applications 2026

Textbook in PDF format

Streamlined, cost-effective, and environmentally benign concepts for the synthesis of chemical building blocks and pharmaceuticals
Directed C—H Bond Functionalization summarizes recent advances in the field of selective and efficient C—H bond functionalization using directing groups.
Written by a team of experts in the field, Directed C—H Bond Functionalization includes information on:
History of the C—H bond activation and its discovery
In-built functional group-directed C—H functionalization, proximal C—H bond functionalization, and template-assisted distal C—H bond functionalization
Transient-directing group-assisted C—H bond functionalization and bifunctional non-covalent template-assisted C—H functionalization
Redox catalytic methods and metal-free directed C—H functionalization reactions
Industrial and synthetic application of directed C—H bond functionalization in organic synthesis, medicinal, and process chemistry
With its all-encompassing approach, Directed C—H Bond Functionalization is a timely, essential reference for synthetic chemists in academia and industry working in the fields of organic synthesis, catalysis, sustainable chemistry, and drug design.
Introduction of C-H Bond Activation
Brief History of C-H Bond Activation and its Discovery
In-Built Functional Group-Directed C-H Functionalization
Traceless Directing Group in C-H Bond Functionalization
Removable Directing Group in Proximal C-H Functionalization
Removable Template-Assisted Distal C-H Functionalization
Transient Directing Group in C-H Bond Functionalization
Bifunctional Non-Covalent Template-Assisted C-H Functionalization
Redox Catalysis in Directed C-H Functionalization
Emerging Metal-Free Directed C-H Functionalization
Industrial and Synthetic Application of Directed C-H Bond Functionalization
Applications in Medicinal and Process Chemistry
Conclusion and Outlook